Trace Amine-Associated Receptor 1 Regulates Central Effects of Monoamine Oxidase Inhibitors: Involvement of Tyramine and Glutamate
نویسندگان
چکیده
SEE CORRESPONDING ARTICLE ON PAGE 16 TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects Monoamine Oxidase InhibitionBiological PsychiatryVol. 90Issue 1PreviewMonoamine oxidase inhibitors (MAOIs) exert therapeutic actions by elevating extracellular levels monoamines the brain. Irreversible MAOIs cause serious hypertensive crises owing to peripheral accumulation tyramine, but role tyramine central effects remains elusive, an issue addressed herein. To achieve robust inhibition MAOA/B, clinically used antidepressant tranylcypromine (TCP) was employed. Full-Text PDF Open Access
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2021
ISSN: ['1873-2402', '0006-3223']
DOI: https://doi.org/10.1016/j.biopsych.2021.04.021